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Article

Testicular Xenografts: A Novel Approach to Study Cytotoxic Damage in Juvenile Primate Testis

1 Apr 2006

Abstract excerpt

The underlying primary damage to the testis caused by chemotherapeutic regimens during childhood is largely unknown. Xenografting of monkey testes was successfully applied in maturation of juvenile testis to the point of complete spermatogenesis. This allows us to manipulate developing primate testis without direct treatment of patients. This new model is validated establishing the effects of cytotoxic treatment...

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PMID: 16585208
DOI: 10.1158/0008-5472.can-05-3754

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