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Tissue-specific effects of in vitro fertilization procedures on genomic cytosine methylation levels in overgrown and normal sized bovine fetuses.

Biology of reproduction - 1 Jul 2006

Hiendleder Stefan, Wirtz Michaela, Mund Cora, Klempt Martina, Reichenbach Horst-Dieter, Stojkovic Miodrag, Weppert Myriam, Wenigerkind Hendrik, Elmlinger Martin, Lyko Frank, Schmitz Oliver J, Wolf Eckhard

Abstract excerpt

Epigenetic perturbations are assumed to be responsible for phenotypic abnormalities of fetuses and offspring originating from in vitro embryo techniques. We studied 29 viable Day-80 bovine fetuses to assess the effects of two in vitro fertilization protocols (IVF1 and IVF2) on fetal phenotype and genomic cytosine methylation levels in liver, skeletal muscle, and brain. The IVF1 protocol employed 0.01 U/ml of FSH...

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PMID: 16554415
DOI: 10.1095/biolreprod.105.043919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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