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Article

Construction and properties of a herpes simplex virus 1 designed to enter cells solely via the IL-13α2 receptor

22 Mar 2006

Abstract excerpt

Current design of genetically engineered viruses for selective destruction of cancer cells is based on the observation that attenuated viruses replicate better in tumor cells than in normal cells. The ideal virus, however, is one that can infect only cancer cells by virtue of altered host range. Such a virus can be made more robust than the highly attenuated viruses used in clinical trials. Earlier, we reported...

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PMID: 16554374
DOI: 10.1073/pnas.0601258103

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