Article
Sequence variability and functional analysis of MutS of hypermutable Pseudomonas aeruginosa cystic fibrosis isolates.
International journal of medical microbiology : IJMM - 1 Aug 2006
Hogardt Michael, Schubert Sören, Adler Kristin, Götzfried Monika, Heesemann Jürgen
Abstract excerpt
In this study, we investigated the variability of MutS among Pseudomonas aeruginosa recovered from cystic fibrosis (CF) patients. Sequencing of the mutS gene of 15 hypermutable P. aeruginosa isolates obtained from different patients revealed high rates of nucleotide substitutions as compared to that of strain PAO1. Significantly more synonymous than non-synonymous nucleotide substitutions have been found,...
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