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Article

Human monogenic disorders - a source of novel drug targets.

Nature reviews. Genetics - 1 Apr 2006

Brinkman Ryan R, Dubé Marie-Pierre, Rouleau Guy A, Orr Andrew C, Samuels Mark E

Abstract excerpt

The decrease in new drug applications and approvals over the past several years results from an underlying crisis in drug target identification and validation. Model organisms are being used to address this problem, in combination with novel approaches such as the International HapMap Project. What has been underappreciated is that discovery of new drug targets can also be revived by traditional Mendelian...

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PMID: 16534513
DOI: 10.1038/nrg1828

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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