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Article

Identification of the minimal protein-folding nucleus through loop-entropy perturbations.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2006

Lindberg Magnus O, Haglund Ellinor, Hubner Isaac A, Shakhnovich Eugene I, Oliveberg Mikael

Abstract excerpt

To explore the plasticity and structural constraints of the protein-folding nucleus we have constructed through circular permutation four topological variants of the ribosomal protein S6. In effect, these topological variants represent entropy mutants with maintained spatial contacts. The proteins were characterized at two complementary levels of detail: by phi-value analysis estimating the extent of contact...

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Identifiers

PMID: 16505376
DOI: 10.1073/pnas.0508863103
PMCID: PMC1449650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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