Article
A Belgian ancestral haplotype harbours a highly prevalent mutation for 17q21-linked tau-negative FTLD.
Brain : a journal of neurology - 1 Apr 2006
van der Zee Julie, Rademakers Rosa, Engelborghs Sebastiaan, Gijselinck Ilse, Bogaerts Veerle, Vandenberghe Rik, Santens Patrick, Caekebeke Jo, De Pooter Tim, Peeters Karin, Lübke Ursula, Van den Broeck Marleen, Martin Jean-Jacques, Cruts Marc, De Deyn Peter P, Van Broeckhoven Christine, Dermaut Bart
Abstract excerpt
Among patients with frontotemporal lobar degeneration (FTLD), the respective frequencies of dominant 17q21-linked tau-negative FTLD (with unidentified molecular defect) and 17q21-linked tau-positive FTLD (due to MAPT mutations) remain unknown. Here, in a series of 98 genealogically unrelated Belgian FTLD patients, we identified an ancestral 8 cM MAPT containing haplotype in two patients belonging to multiplex...
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