Article
Analysis of the full-length genome of genotype 4 hepatitis E virus isolates from patients with fulminant or acute self-limited hepatitis E.
Journal of medical virology - 1 Apr 2006
Inoue Jun, Nishizawa Tsutomu, Takahashi Masaharu, Aikawa Tatsuya, Mizuo Hitoshi, Suzuki Kazuyuki, Shimosegawa Tooru, Okamoto Hiroaki
Abstract excerpt
It was suggested that hepatitis E virus (HEV) genotype 4 is associated more closely with the severity of hepatitis E than genotype 3, although the virological basis remains unknown. The aim of this study was to examine whether genomic differences among genotype 4 HEVs are responsible for the development of fulminant hepatitis. Full-length sequences of genotype 4 HEVs from three patients with fulminant hepatitis...
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