Article
Quantitative determination of haptoglobin glycoform variants in psoriasis.
Biological chemistry - 1 Dec 2010
Maresca Bernardetta, Cigliano Luisa, Corsaro Maria M, Pieretti Giuseppina, Natale Massimo, Bucci Enrico M, Dal Piaz Fabrizio, Balato Nicola, Nino Massimiliano, Ayala Fabio, Abrescia Paolo
Abstract excerpt
Haptoglobin is an acute phase glycoprotein, secreted by hepatocytes and other types of cells including keratinocytes. Haptoglobin has been suggested to impair the immune response, inhibit gelatinases in the extracellular matrix and promote angiogenesis, but its role in psoriasis is obscure to date. Changes in haptoglobin glycan structure were observed in several diseases. The aim of this study was to investigate...
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