Article
High prevalence of Streptococcus pneumoniae with mutations in pbp1a, pbp2x, and pbp2b genes of penicillin-binding proteins in the nasopharynx in children in Japan.
ORL; journal for oto-rhino-laryngology and its related specialties - 1 Jan 2006
Hotomi Muneki, Billal Dewan S, Shimada Jun, Suzumoto Masaki, Yamauchi Kazuma, Fujihara Keiji, Yamanaka Noboru
Abstract excerpt
OBJECTIVE: To evaluate the resistances of Streptococcus pneumoniae to beta-lactams developed by stepwise alterations in high-molecular-weight penicillin-binding proteins (PBPs) with a reduced binding affinity of beta-lactams. Among the numerous mutations in pbp genes that alter the affinity for b...
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