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Article

Both N-terminal and C-terminal regions of steroid sulfatase are important for enzyme activity.

The Journal of endocrinology - 1 Feb 2006

Sugawara T, Nomura E, Hoshi N

Abstract excerpt

Steroid sulfatase (STS) is localized in the endoplasmic reticulum and catalyzes desulfation of 3beta-hydroxysteroid sulfates. X-linked ichthyosis (XLI) is an inherited skin disorder caused by deficiency of STS enzyme activity. We previously reported a case in which XLI with a one-base change in the STS gene and variation in amino acid Q560P developed. In this study, we performed molecular analysis to determine...

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Identifiers

PMID: 16461562
DOI: 10.1677/joe.1.06417

Genes

STS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Both N-terminal and C-terminal regions of steroid sulfatase are important for enzyme activity.PMID 16461562Read ↗

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Molecular analysis of SUMF1 mutations: stability and residual activity of mutant formylglycine-generating enzyme determine disease severity in multiple sulfatase deficiency.Semantic proximity Read ↗

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