Article
[Detoxication gene polymorphism and susceptibility to sporadic motor neuron disease in Russian population].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova - 1 Jan 2006
Skvortsova V I, Slominskiĭ P A, Shadrina M I, Levitskiĭ G N, Levitskaia N I, Alekhin A V, Zherebtsova A L, Serdiuk A V, Limborskaia S A
Abstract excerpt
Motor neuron disease (MND) is caused by selective degeneration of motor neurons of the cerebral cortex, brain stem and spinal cord. Many genetic systems are thought to be involved in pathogenesis of this complex disease. A significant etiological factor of MND may be oxygen free radicals, which damage neuronal cells when they are present in high concentrations. Detoxication processes resulting in the formation of...
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