Article
Gene therapy in systemic lupus erythematosus.
Current gene therapy - 1 Dec 2005
Kyttaris V C, Sfikakis P P, Juang Y-T, Tsokos G C
Abstract excerpt
Despite the fact that the etiopathogenesis of systemic lupus erythematosus is largely unknown, key steps in the pathophysiology of the disease have been recognized and targeted using gene therapy techniques. In animal models of lupus, gene transfer has been used to block the action of pro-inflammatory cytokines and co-stimulatory molecules leading to clinical improvement. In humans, ex vivo experiments have shown...
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