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Cellular Senescence in Aging Primates

2 Feb 2006

Abstract excerpt

The aging of organisms is characterized by a gradual functional decline of all organ systems. Mammalian somatic cells in culture display a limited proliferative life span, at the end of which they undergo an irreversible cell cycle arrest known as replicative senescence. Whether cellular senescence contributes to organismal aging has been controversial. We investigated telomere dysfunction, a recently discovered...

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PMID: 16456035
DOI: 10.1126/science.1122446

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