Article
Atmnd1-delta1 is sensitive to gamma-irradiation and defective in meiotic DNA repair.
DNA repair - 8 Apr 2006
Domenichini Séverine, Raynaud Cécile, Ni Di-An, Henry Yves, Bergounioux Catherine
Abstract excerpt
The efficient repair of double-strand breaks (DSBs) in genomic DNA is crucial for the survival of all organisms. Mnd1 is suggested to promote the strand invasion step during meiotic recombination. We used a forward genetics approach, through the search for mutants, to characterize the Arabidopsis homologue of Mnd1. Atmnd1 null mutants exhibit normal vegetative and flower development. In contrast, during prophase...
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