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Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium

24 Jan 2006

Abstract excerpt

The cilium/flagellum is a sensory-motile organelle ancestrally present in eukaryotic cells. For assembly cilia universally rely on intraflagellar transport (IFT), a specialised bidirectional transport process mediated by the ancestral and conserved IFT complex. Based on the homology of IFT complex proteins to components of coat protein I (COPI) and clathrin-coated vesicles, we propose that the non- vesicular,...

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PMID: 16435301
DOI: 10.1002/bies.20369

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