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Impairment of spermatogenesis and enhancement of testicular germ cell apoptosis induced by exogenous all-Trans-retinoic acid in adult lizardPodarcis sicula

1 Jan 2006

Abstract excerpt

In mammals, retinoic acid is involved in the regulation of testicular function by interaction with two families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR). Among RAR isoforms, the testicular cells of the lizard were found to express only RARalpha (3.7 kb) and RARbeta (3.4 kb) mRNAs, as reported here. In this study, the effects of exogenous all-trans-retinoic acid (atRA) on...

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PMID: 16432891
DOI: 10.1002/jez.a.264

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