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Article

Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells.

The EMBO journal - 13 Dec 2006

Vernet Nadège, Dennefeld Christine, Guillou Florian, Chambon Pierre, Ghyselinck Norbert B, Mark Manuel

Abstract excerpt

Sertoli cells (SC) are instrumental to stem spermatogonia differentiation, a process that critically depends on retinoic acid (RA). We show here that selective ablation of RA receptor alpha (RARalpha) gene in mouse SC, singly (Rara(Ser-/-) mutation) or in combination with RARbeta and RARgamma genes (Rara/b/g(Ser-/-) mutation), abolishes cyclical gene expression in these cells. It additionally induces testis...

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Identifiers

PMID: 17124491
DOI: 10.1038/sj.emboj.7601447
PMCID: PMC1698894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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