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Article

Phenotypic analysis of mice lacking the Tmprss2-encoded protease.

Molecular and cellular biology - 1 Feb 2006

Kim Tom S, Heinlein Cynthia, Hackman Robert C, Nelson Peter S

Abstract excerpt

Tmprss2 encodes an androgen-regulated type II transmembrane serine protease (TTSP) expressed highly in normal prostate epithelium and has been implicated in prostate carcinogenesis. Although in vitro studies suggest protease-activated receptor 2 may be a substrate for TMPRSS2, the in vivo biological activities of TMPRSS2 remain unknown. We generated Tmprss2-/- mice by disrupting the serine protease domain through...

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Identifiers

PMID: 16428450
DOI: 10.1128/MCB.26.3.965-975.2006
PMCID: PMC1347042

Genes

TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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