Mast cell changes in scleroderma. Presence of MCT cells in the skin and evidence of mast cell activation.

doi:10.1002/art.1780350813

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Article

Mast cell changes in scleroderma. Presence of MCT cells in the skin and evidence of mast cell activation.

Arthritis and rheumatism - 1 Aug 1992

Irani A M, Gruber B L, Kaufman L D, Kahaleh M B, Schwartz L B

Abstract excerpt

OBJECTIVE: To analyze the concentration and distribution of the MCT (tryptase-positive, chymase-negative) and MCTC (tryptase-positive, chymase-positive) types of mast cell in cutaneous lesions of scleroderma. METHODS: Biopsy specimens were obtained from skin lesions in 24 patients with scleroderm...

Topics

Adult
Antibodies, Monoclonal
Biopsy
Cell Count
Chymases
Female
Humans
Immunohistochemistry
Male
Mast Cells
Middle Aged
Peptide Hydrolases
Phenotype
Scleroderma, Systemic
Serine Endopeptidases
Skin

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