Article
Mast cell changes in scleroderma. Presence of MCT cells in the skin and evidence of mast cell activation.
Arthritis and rheumatism - 1 Aug 1992
Irani A M, Gruber B L, Kaufman L D, Kahaleh M B, Schwartz L B
Abstract excerpt
OBJECTIVE: To analyze the concentration and distribution of the MCT (tryptase-positive, chymase-negative) and MCTC (tryptase-positive, chymase-positive) types of mast cell in cutaneous lesions of scleroderma. METHODS: Biopsy specimens were obtained from skin lesions in 24 patients with scleroderma, and subjected to double immunohistochemical analysis using mouse monoclonal anti-tryptase and anti-chymase...
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