Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation in the Sp1 motif of the bovine leptin gene affects its expression.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 2006

Adamowicz Tatiana, Flisikowski Krzysztof, Starzyński Rafał, Zwierzchowski Lech, Switoński Marek

Abstract excerpt

Leptin is expressed mainly by adipocytes and plays a crucial role in the regulation of energy expenditure, food intake, and adiposity. Using PCR-heteroduplex analysis and sequencing, we investigated a C/G substitution in the promoter region of the bovine leptin gene. Application of the electrophoretic mobility shift assay showed that the C-->G transversion decreased the leptin gene promoter binding capacity for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cattle
Share to DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Probes

Share to Gene Expression Regulation

Share to Leptin

Share to Polymerase Chain Reaction

Share to Promoter Regions, Genetic

Share to Sp1 Transcription Factor

Source

Identifiers

PMID: 16416093
DOI: 10.1007/s00335-005-0068-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation in the Sp1 motif of the bovine leptin gene affects its expression.PMID 16416093Read ↗

Polymorphisms in the leptin gene promoter in Brazilian beef herds.Semantic proximity Read ↗

Effect of the leptin c.73T>C mutation on carcass traits in beef cattle.Semantic proximity Read ↗

Polymorphisms in the bovine leptin promoter associated with serum leptin concentration, growth, feed intake, feeding behavior, and measures of carcass merit.Semantic proximity Read ↗

Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels.Semantic proximity Read ↗

Leptin promoter mutations affect leptin levels and performance traits in dairy cows.Semantic proximity Read ↗

Identification and genetic effects of a novel polymorphism in the distal promoter region of porcine leptin gene.Semantic proximity Read ↗

Biochemical and in vitro biological significance of natural sequence variation in the ovine leptin gene.Semantic proximity Read ↗

Polymorphism of the porcine leptin gene promoter and analysis of its association with gene expression and fatness traits.Semantic proximity Read ↗

Effects of a single nucleotide polymorphism in the leptin gene on the productive traits of dairy buffaloes (Bubalus bubalis).Semantic proximity Read ↗

The involvement of leptin in humans revealed by mutations in leptin and leptin receptor genes.Semantic proximity Read ↗

Detection of polymorphism within leptin gene in Egyptian river buffalo and predict its effects on different molecular levelsSemantic proximity Read ↗

[Analysis of SNPs in exons 2 and 3 of the leptin gene in wild boar, swine and hybrid swine].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.