Article
Common promoter polymorphism in monocyte differentiation antigen CD14 is associated with serum triglyceride levels and body mass index in non-diabetic individuals.
Diabetic medicine : a journal of the British Diabetic Association - 1 Jan 2006
Shin H D, Park K S, Park B L, Cheong H S, Cho Y M, Lee H K, Lee J-Y, Lee J-K, Kim H T, Han B G, Kim J W, Koh I, Kim Y J, Oh B, Kimm K, Park C
Abstract excerpt
AIMS: Growing evidence supports the hypothesis that chronic low-grade inflammation related to innate immunity may play an important role in the pathophysiology of Type 2 diabetes mellitus (T2DM). The monocyte differentiation antigen CD14 gene (CD14) acts as the receptor for lipopolysaccharide (LPS) and augments monocyte/macrophage inflammatory responses. METHODS: We have sequenced the gene, including all exons,...
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