Construction of a multivalent meningococcal vaccine strain based on the class 1 outer membrane protein

Abstract excerpt

Outer membrane complexes (OMCs) are promising vaccine candidates for protection against meningococcal disease. However, a major obstacle to this approach is the fact that the protective antibodies induced are generally type specific. In an attempt to overcome this problem, we have investigated the possibility of constructing a multivalent vaccine strain by insertion of an additional class 1 outer membrane...

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