Article
Discriminating power of localized three-dimensional facial morphology.
American journal of human genetics - 1 Dec 2005
Hammond Peter, Hutton Tim J, Allanson Judith E, Buxton Bernard, Campbell Linda E, Clayton-Smith Jill, Donnai Dian, Karmiloff-Smith Annette, Metcalfe Kay, Murphy Kieran C, Patton Michael, Pober Barbara, Prescott Katrina, Scambler Pete, Shaw Adam, Smith Ann C M, Stevens Angela F, Temple I Karen, Hennekam Raoul, Tassabehji May
Abstract excerpt
Many genetic syndromes involve a facial gestalt that suggests a preliminary diagnosis to an experienced clinical geneticist even before a clinical examination and genotyping are undertaken. Previously, using visualization and pattern recognition, we showed that dense surface models (DSMs) of full face shape characterize facial dysmorphology in Noonan and in 22q11 deletion syndromes. In this much larger study of...
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