Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nostocarboline: Isolation and Synthesis of a New Cholinesterase Inhibitor from<i>Nostoc</i>78-12A

1 Dec 2005

Abstract excerpt

A new quaternary beta-carboline alkaloid, nostocarboline, was isolated from the freshwater cyanobacterium Nostoc 78-12A, and its constitution was assigned by 2D-NMR methods. The structure was proven by its total synthesis starting from norharmane via chlorination at C-6 and methylation at N-2. Nostocarboline was found to be a potent butyrylcholinesterase (BChE) inhibitor, with an IC(50) of 13.2 microM. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemical synthesis and alkaloids
Share to Cholinesterase and Neurodegenerative Diseases

Source

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 16378379
DOI: 10.1021/np050312l

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Nostocarboline: Isolation and Synthesis of a New Cholinesterase Inhibitor from<i>Nostoc</i>78-12APMID 16378379Read ↗

Novel thiazolidinedione hybrids as cholinesterase inhibitors and targeting neuroblastoma: design, synthesis, in vitro and in silico biological evaluationsSemantic proximity Read ↗

Design, synthesis, in vitro and in vivo evaluation of tacrine–cinnamic acid hybrids as multi-target acetyl- and butyrylcholinesterase inhibitors against Alzheimer's diseaseSemantic proximity Read ↗

Molecular dissection of cholinesterase domains responsible for carbamate toxicity.Semantic proximity Read ↗

Cholinesterase activity and effects of its inhibition by neurotoxic drugs in Dictyostelium discoideumSemantic proximity Read ↗

Apratoxin H and Apratoxin A Sulfoxide from the Red Sea Cyanobacterium <i>Moorea producens</i>Semantic proximity Read ↗

Bioactive Tyrosine‐Derived Cytochalasins from Fungus <i>Eutypella</i> sp. D‐1Semantic proximity Read ↗

Toluidine blue O is a potent inhibitor of human cholinesterases.Semantic proximity Read ↗

Syntheses and biological properties of cysteine-reactive epibatidine derivatives.Semantic proximity Read ↗

Membrane effects of toxins isolated from a cyanobacterium, Cylindrospermopsis raciborskii, on identified molluscan neuronesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.