Article
The ompA gene in Chlamydia trachomatis differs in phylogeny and rate of evolution from other regions of the genome.
Infection and immunity - 1 Jan 2006
Brunelle Brian W, Sensabaugh George F
Abstract excerpt
Strains of Chlamydia trachomatis are classified into serovars based on nucleotide sequence differences in ompA, the gene that encodes the major outer membrane protein. Phylogenetic characterization of strains based on ompA, however, results in serovar groupings that are inconsistent with the distinguishing features of C. trachomatis pathobiology, e.g., tissue tropisms and disease presentation. We have compared...
Topics
- Animals
- Bacterial Outer Membrane Proteins
- Chlamydia Infections
- Chlamydia trachomatis
- Evolution, Molecular
- Genetic Variation
- Humans
- Mice
- Phylogeny
- Recombination, Genetic
- Serotyping