Article
Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia.
Cancer research - 15 Dec 2005
van der Schaft Daisy W J, Hillen Femke, Pauwels Patrick, Kirschmann Dawn A, Castermans Karolien, Egbrink Mirjam G A Oude, Tran Maxine G B, Sciot Rafael, Hauben Esther, Hogendoorn Pancras C W, Delattre Olivier, Maxwell Patrick H, Hendrix Mary J C, Griffioen Arjan W
Abstract excerpt
A striking feature of Ewing sarcoma is the presence of blood lakes lined by tumor cells. The significance of these structures, if any, is unknown. Here, we report that the extent of blood lakes correlates with poor clinical outcomes, whereas variables of angiogenesis do not. We also show that Ewing sarcoma cells form vessel-like tubes in vitro and express genes associated with vasculogenic mimicry. In tumor...
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