Article
Genomic investigations of posterior uveal melanoma.
Seminars in ophthalmology - 1 Jan 2000
Hovland Peter G, Trempe Clement
Abstract excerpt
The specific genetic mechanisms responsible for the malignant behavior of uveal melanoma are not known. Unlike cutaneous melanoma, epidemiologic studies have not demonstrated a definitive germline form of uveal melanoma, though familial melanoma and racial predilections occur. Molecular cytogenetic characterization of uveal melanoma suggests that somatic deletions of chromosome 3 are associated with a worse...
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