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A method for accurate detection of genomic microdeletions using real-time quantitative PCR

1 Dec 2005

Abstract excerpt

BACKGROUND: Quantitative Polymerase Chain Reaction (qPCR) is a well-established method for quantifying levels of gene expression, but has not been routinely applied to the detection of constitutional copy number alterations of human genomic DNA. Microdeletions or microduplications of the human genome are associated with a variety of genetic disorders. Although, clinical laboratories routinely use fluorescence in...

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PMID: 16351727
DOI: 10.1186/1471-2164-6-180

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