Article
Vaccination of chicken embryos with escape mutants of La Sota Newcastle disease virus induces a protective immune response.
Vaccine - 10 Mar 2006
Mast Jan, Nanbru Cécile, Decaesstecker Mireille, Lambrecht Bénédicte, Couvreur Bernard, Meulemans Guy, van den Berg Thierry
Abstract excerpt
To reduce the embryonic pathogenicity of Newcastle disease virus (NDV), escape mutants of the La Sota strain were produced with selected monoclonal antibodies. Immunoselection resulted in the elimination of an epitope by single amino acid substitution (F and HN molecule) or in a conformational change (HN molecule). The embryonic pathogenicity of these escape mutants was reduced and their dose was optimised for in...
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