Article
Targeting the stromal fibroblasts: a novel approach to melanoma therapy.
Expert review of anticancer therapy - 1 Dec 2005
Smalley Keiran S M, Lioni Mercedes, Herlyn Meenhard
Abstract excerpt
Classically, cancer is thought of as a genetic disease, where the step-wise acquisition of mutations initiates and drives progression. More recent thinking posits that, although cancers are initiated through genetic mutation, progression is often the result of dynamic interactions between the tumor cells and their surrounding environment.
Topics
- Cell Adhesion
- Cell Communication
- Disease Progression
- Drug Resistance, Neoplasm
- Fibroblasts
- Humans
- Keratinocytes
- Melanoma
- Neoplasm Invasiveness
- Neovascularization, Pathologic
- Phenotype
- Skin Neoplasms
- Stromal Cells
- Transforming Growth Factor beta