Article
The associations of p53 overexpression with p53 codon 72 genetic polymorphism in esophageal cancer.
Mutation research - 22 Feb 2006
Lee Jang-Ming, Shun Chia-Tung, Wu Ming-Tsang, Chen Yun-Yen, Yang Shi-Yi, Hung Hsi-I, Chen Jin-Shing, Hsu Hsau-Hsun, Huang Pei-Ming, Kuo Shuenn-Wen, Lee Yung-Chie
Abstract excerpt
Variations in p53 codon 72 have been identified as significant predisposing factors for various cancers, but molecular mechanisms remain unclear. We investigated associations of p53 overexpression with codon 72 variants and other factors with esophageal cancer. Status of p53 overexpression was determined by immunohistochemical staining. Codon 72 polymorphisms and mutation of p53 was identified by PCR-RFLP and...
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