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Article

Pax1/E2a double-mutant mice develop non-lethal neural tube defects that resemble human malformations.

Transgenic research - 1 Dec 2005

Joosten Paulus H L J, van Zoelen Everardus J J, Murre Cornelis

Abstract excerpt

Many mouse models exist for neural tube defects (NTDs), but only few of them are relevant for human patients that are born alive with spina bifida aperta. NTDs in humans show a complex inheritance, which most likely result from the involvement of a variety of predisposing genetic and environmental factors. Hints toward the identity of predisposing genetic factors for human NTDs could come from mouse studies on...

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PMID: 16315099
DOI: 10.1007/s11248-005-2540-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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