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Article

Prothrombotic mutations, hormone therapy, and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration.

Circulation - 29 Nov 2005

Straczek Céline, Oger Emmanuel, Yon de Jonage-Canonico Marianne Beau, Plu-Bureau Geneviève, Conard Jacqueline, Meyer Guy, Alhenc-Gelas Martine, Lévesque Hervé, Trillot Nathalie, Barrellier Marie-Thérèse, Wahl Denis, Emmerich Joseph, Scarabin Pierre-Yves

Abstract excerpt

BACKGROUND: Oral estrogen increases the risk of venous thromboembolism (VTE) in postmenopausal women, particularly in those with a prothrombotic mutation. Transdermal estrogen may be safe with respect to VTE. We investigated the impact of the route of estrogen administration on the association between a prothrombotic mutation (factor V Leiden or prothrombin G20210A mutation) and VTE risk. METHODS AND RESULTS: We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16301339
DOI: 10.1161/CIRCULATIONAHA.105.565556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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