Evaluation of Hox11L1 in the fmc/fmc rat model of chronic intestinal pseudo-obstruction.

Abstract excerpt

BACKGROUND/PURPOSE: The spontaneous rat mutation, familial megacecum and colon (fmc), is responsible for an autosomal recessive phenotype similar to intestinal pseudo-obstruction observed in Hox11L1-/- mice. We hypothesized that fmc is a mutant allele of the rat Hox11L1 gene and tested this hypothesis by direct sequencing. METHODS: DNA was extracted from fmc/fmc rats and wild-type littermates. All exons, introns,...

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