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High-throughput MS-based protein phenotyping: application to haptoglobin.

Proteomics - 1 Dec 2005

Tubbs Kemmons A, Kiernan Urban A, Niederkofler Eric E, Nedelkov Dobrin, Bieber Allan L, Nelson Randall W

Abstract excerpt

A high-throughput affinity capture and reduction approach was developed for phenotype and post-translational modification analysis of a complexed globular protein, haptoglobin (Hp), directly from human plasma. Hp was selectively retrieved utilizing anti-Hp antibodies immobilized onto affinity pipette tips, eluted onto a formatted mass spectrometer target for reduction of Hp alpha-chains (Hpalpha1 and Hpalpha2)...

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PMID: 16281186
DOI: 10.1002/pmic.200500176

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