Article
Essential role of aralar in the transduction of small Ca2+ signals to neuronal mitochondria.
The Journal of biological chemistry - 13 Jan 2006
Pardo Beatriz, Contreras Laura, Serrano Antonio, Ramos Milagros, Kobayashi Keiko, Iijima Mikio, Saheki Takeyori, Satrústegui Jorgina
Abstract excerpt
Aralar, the neuronal Ca(2+)-binding mitochondrial aspartate-glutamate carrier, has Ca(2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS). Here we showed that MAS activity in brain mitochondria is stimulated by extramitochondrial Ca(2+) with an S(0.5) of 324 nM. By employing primary neuronal cultures from control and aralar-deficient mice and NAD(P)H...
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