Article
Intracellular interference of infectious bursal disease virus.
Journal of virology - 1 Nov 2005
González Dolores, Rodríguez Jose Francisco, Abaitua Fernando
Abstract excerpt
A search for dominant-negative mutant polypeptides hampering infectious bursal disease virus (IBDV) replication has been undertaken. We have found that expression of a mutant version of the VP3 structural polypeptide known as VP3/M3, partially lacking the domain responsible for the interaction with the virus-encoded RNA polymerase, efficiently interferes with the IBDV replication cycle. Transformed cells stably...
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