Proteasome subunit LMP2 is required for matrix metalloproteinase‐2 and ‐9 expression and activities in human invasive extravillous trophoblast cell line

Abstract excerpt

The ubiquitin-proteasome pathway (UPP) is involved in the degradation of the extracellular matrix (ECM) and trophoblastic invasion during early pregnancy. Our previous studies demonstrated that inhibition of UPP suppresses expression of matrix metalloproteinase (MMP)-2 and -9. LMP2 is an important proteasome subunit that is critical for proteasome activity. This study investigated the regulatory mechanism of LMP2...

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