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Article

<i>HER2</i> Amplification and Overexpression Is Not Present in Pediatric Osteosarcoma: A Tissue Microarray Study

1 Sept 2005

Abstract excerpt

The HER2 gene, located on 17q, encodes a 185-kD transmembrane tyrosine kinase receptor. Amplification of this gene with overexpression of the gene product occurs in about 30% of cases of breast cancer and is considered to be a poor prognostic indicator for this tumor. Results for HER2 expression in osteosarcoma are controversial, with some studies reporting up to 61% of positive cases and others reporting only...

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PMID: 16211448
DOI: 10.1007/s10024-005-0044-5

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