Article
Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2008
Dorfmeister B, Zeng W W, Dichlberger A, Nilsson S K, Schaap F G, Hubacek J A, Merkel M, Cooper J A, Lookene A, Putt W, Whittall R, Lee P J, Lins L, Delsaux N, Nierman M, Kuivenhoven J A, Kastelein J J P, Vrablik M, Olivecrona G, Schneider W J, Heeren J, Humphries S E, Talmud P J
Abstract excerpt
OBJECTIVE: The purpose of this study was to identify rare APOA5 variants in 130 severe hypertriglyceridemic patients by sequencing, and to test their functionality, since no patient recall was possible. METHODS AND RESULTS: We studied the impact in vitro on LPL activity and receptor binding of 3...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.