Article
Evaluation of the role of Valosin-containing protein in the pathogenesis of familial and sporadic Paget's disease of bone.
Bone - 1 Feb 2006
Lucas Gavin J A, Mehta Sarju G, Hocking Lynne J, Stewart Tracy L, Cundy Tim, Nicholson Geoff C, Walsh John P, Fraser William D, Watts Giles D J, Ralston Stuart H, Kimonis Virginia E
Abstract excerpt
Paget's disease of bone (PDB) is a common metabolic bone disease of late onset with a strong genetic component. Rarely, PDB can occur as part of a syndrome in which the disease is accompanied by inclusion body myopathy and frontotemporal dementia (inclusion body myopathy, Paget's disease and frontotemporal dementia, IBMPFD). Recently, IBMPFD has been shown to be caused by mutations in Valosin-containing Protein...
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