Article
Short-term safety and pharmacodynamics of amdoxovir in HIV-infected patients.
AIDS (London, England) - 14 Oct 2005
Thompson Melanie A, Kessler Harold A, Eron Joseph J, Jacobson Jeffrey M, Adda Nathalie, Shen Gong, Zong Jian, Harris Jeanette, Moxham Cary, Rousseau Franck S
Abstract excerpt
OBJECTIVES: To evaluate the pharmacodynamics and safety of escalating doses of amdoxovir (DAPD) monotherapy administered to treatment-naive and experienced HIV-1-infected patients over 15 days. DESIGN: Ninety patients with plasma HIV-1 RNA levels between 5000 and 250,000 copies/ml were randomized to DAPD 25, 100, 200, 300 or 500 mg twice daily or 600 mg once daily monotherapy [antiretroviral therapy (ART)-naive...
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