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Article

KCNH2-K897T is a genetic modifier of latent congenital long-QT syndrome.

Circulation - 30 Aug 2005

Crotti Lia, Lundquist Andrew L, Insolia Roberto, Pedrazzini Matteo, Ferrandi Chiara, De Ferrari Gaetano M, Vicentini Alessandro, Yang Ping, Roden Dan M, George Alfred L, Schwartz Peter J

Abstract excerpt

BACKGROUND: Clinical heterogeneity among patients with long-QT syndrome (LQTS) sharing the same disease-causing mutation is usually attributed to variable penetrance. One potential explanation for this phenomenon is the coexistence of modifier gene alleles, possibly common single nucleotide polymorphisms, altering arrhythmia susceptibility. We demonstrate this concept in a family segregating a novel,...

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Topics

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Share to Death, Sudden, Cardiac
Share to Electrocardiography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ERG1 Potassium Channel

Share to Ether-A-Go-Go Potassium Channels

Share to Long QT Syndrome

Share to Mutation

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Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 16116052
DOI: 10.1161/CIRCULATIONAHA.105.549071

Genes

KCNH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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