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Article

Tick saliva is a potent inhibitor of endothelial cell proliferation and angiogenesis

1 Jan 2005

Abstract excerpt

We report for the first time that saliva of the hard tick and Lyme disease vector, Ixodes scapularis, is a potent inhibitor of angiogenesis. Saliva (< or = 1:500 dilutions) or salivary gland (0.1-0.5 pairs/assay) dose-dependently inhibits microvascular endothelial cell (MVEC) proliferation. Inhibition was also detected with the saliva of the cattle tick Boophilus microplus but not with the salivary gland of...

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PMID: 16113800
DOI: 10.1160/th04-09-0566

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