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Article

CADASIL with NOTCH3 S180C presenting anticipation of onset age and hallucinations.

Journal of the neurological sciences - 15 Nov 2005

Nakamura Tomohiko, Watanabe Hirohisa, Hirayama Masaaki, Inukai Akira, Kabasawa Hidehiro, Matsubara Michitaka, Mitake Shigehisa, Nakamura Masaaki, Ando Yukio, Uchino Makoto, Sobue Gen

Abstract excerpt

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited disease leading to strokes and vascular dementia. The average age of onset for stroke is 45 years with a range of about 30 to 70 years. We describe a Japanese CADASIL family showing S180C in the exon 4 of NOTCH3, presenting an anticipation of the onset age for stroke. MRI demonstrated a similar...

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Source

Identifiers

PMID: 16111703
DOI: 10.1016/j.jns.2005.07.001

Genes

NOTCH3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CADASIL with NOTCH3 S180C presenting anticipation of onset age and hallucinations.PMID 16111703Read ↗

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