Article
Alpha-thalassaemia and population health in Southeast Asia.
Annals of human biology - 1 Jan 2000
Chui David H K
Abstract excerpt
Alpha-thalassaemia mutations are common. In Southeast Asia, they cause Hb H disease and Hb Barts hydrops fetalis. Fetuses with the devastating Hb Barts hydrops fetalis due to the complete lack of alpha-globin gene die in utero or shortly after birth, often during the second or third trimesters. Recent findings on patients with Hb H disease who have only one active alpha-globin gene suggest that it is not...
Topics
- Asia, Southeastern
- Female
- Genetic Counseling
- Genetic Testing
- Globins
- Hemoglobin H
- Humans
- Mutation
- Pregnancy
- Prenatal Diagnosis
- alpha-Thalassemia
