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Article

Transcriptional profiling of a mouse model for Lafora disease reveals dysregulation of genes involved in the expression and modification of proteins.

Neuroscience letters - 21 Oct 2005

Ganesh Subramaniam, Tsurutani Naomi, Amano Kenji, Mittal Shuchi, Uchikawa Chiharu, Delgado-Escueta Antonio V, Yamakawa Kazuhiro

Abstract excerpt

Lafora's progressive myoclonus epilepsy (Lafora disease: LD) is caused by mutations in the EPM2A or NHLRC1 gene, but cellular mechanisms of the pathogenesis remain unclear. In an attempt to understand and elucidate the disease pathway, we have investigated the global gene expression profile in a mouse model for LD that developed a phenotype similar to that observed in human patients, including presence of Lafora...

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Identifiers

PMID: 16084644
DOI: 10.1016/j.neulet.2005.07.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transcriptional profiling of a mouse model for Lafora disease reveals dysregulation of genes involved in the expression and modification of proteins.PMID 16084644Read ↗

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