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Article

Guilty by association: some collagen II mutants alter the formation of ECM as a result of atypical interaction with fibronectin.

Journal of molecular biology - 16 Sept 2005

Ito Hidetoshi, Rucker Eileen, Steplewski Andrzej, McAdams Erin, Brittingham Raymond J, Alabyeva Tatiana, Fertala Andrzej

Abstract excerpt

Among the structural components of extracellular matrices (ECM) fibrillar collagens play a critical role, and single amino acid substitutions in these proteins lead to pathological changes in tissues in which they are expressed. Employing a biologically relevant experimental model consisting of cells expressing R75C, R519C, R789C, and G853E procollagen II mutants, we found that the R789C mutation causing a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16083907
DOI: 10.1016/j.jmb.2005.07.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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