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Article

Does complement factor B have a role in the pathogenesis of atypical HUS?

Molecular immunology - 1 Mar 2006

Kavanagh David, Kemp Elizabeth J, Richards Anna, Burgess Rachel M, Mayland Elizabeth, Goodship Judith A, Goodship Timothy H J

Abstract excerpt

Atypical haemolytic uraemic syndrome (aHUS) is a disorder of complement dysregulation. Because complement factor B (fB) carries the catalytic site of the alternative pathway convertase we examined it as both a potential candidate gene and modifier in the pathogenesis of aHUS. No factor B gene (BF) mutations were found in 20 patients with aHUS. There was no statistical difference between controls and aHUS patients...

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Source

Identifiers

PMID: 16061287
DOI: 10.1016/j.molimm.2005.06.041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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